Welcome to my research portfolio. This repository not only hosts the research projects I'm working on but also some naive ideas and proposals that will become reality someday. Or maybe just a repository for my personal experiences exploring the human brain and cognition.
Welcome to my research portfolio. My current interests sit at the intersection of computational neuroscience and neuroengineering, especially in speech decoding, learning and memory, and spatial navigation. I'm exploring implementing human cognition into brain-computer interfaces.
Besides from the research, I love to play soccer, watch Premier League and Formula one. I like hiking, hanging out with friends to do photography.
We discovered CA1 population activity uses a disentangled code for location, time, and choice. CA3 and MEC inputs set spatial remapping, while local CA1 PV-interneuron drives representational drift.
View preprintWe investigated the behavior of male mice living in a semi-natural outdoor enclosure and studied hippocampal place cell activity as they formed, defended, and intruded into territory.
We developed a polymer-based flexible thin-film probe to overcome tissue-device mismatch seen with rigid silicon probes, enabling long-term single-neuron tracking.
A closed-loop BMI experiment to investigate whether hippocampal sequences function as prioritized experience replay by selectively reinforcing high-value trajectories in real time to accelerate learning in a probabilistic T-maze task.
A developing proposal focused on how pathological circuit changes may reshape drift, destabilize neural manifolds, and impair stable memory representations in disease.
If you are interested, you can also explore work I completed in Dr. Chenjian Li's lab at Peking University on Huntington's disease using the CRISPR system. It marks an earlier stage in my research journey and reflects how my interests grew from molecular questions toward systems and computational neuroscience.
Related publication: Yuanyi Dai et al., Self-inactivating AAV-CRISPR at different ages enables sustained amelioration of Huntington’s disease deficits in BAC226Q mice. Sci. Adv. 12, eaea8052 (2026). DOI:10.1126/sciadv.aea8052
If any project, proposal, or research direction here resonates with you, feel free to reach out. I would be glad to connect around neuroscience, neuroengineering, memory circuits, or brain-machine interfaces.