Project Drift
A hippocampal population code for rapid generalization
CA1 population activity uses a disentangled code for location, time, and choice, while CA3,
MEC, and local PV-interneurons shape remapping and representational drift.
Status: Pre-print
• Conducted mouse behavioral tasks, Arduino coding, mouse optogenetic fiber surgery, perfusion, and imaging
• Individual mini project: investigated topological data analysis, high dimensionality reduction, and hippocampal neural manifold analysis in 1) familiar vs. unfamiliar tracks 2) and changes across long-term recording (~300 days using flexible probe)
Project Territory
A socio-spatial cognitive map of naturalistic environment
We study male mice in a semi-natural outdoor enclosure to understand how hippocampal place
cell activity evolves during territory formation, defense, and intrusion.
Status: In prep / unpublished manuscript
• Performed Neuropixels silicon probe surgeries and executed naturalistic outdoor behavioral tasks (territory competition) using wireless neuro-datalogger setups
• Designed 3D-printed headstages and involved in building automated pipelines for multi-animal identity tracking, combining mouse trajectory and IMU data with PCB/CE32 console recordings
• Analyzed high-dimensional neural population dynamics, performing spike sorting, DeepLabCut, Yolo, sharp- wave ripple detection, analyzing cell metrics and unique place cell properties under different territories and behavioral tasks, and modeling theta sweeps and neural manifold topology
Project Fabrication
Long-term, large-scale neural recordings across memory circuits with high-density flexible probes
This work develops polymer-based flexible thin-film probes to reduce tissue-device mismatch
and support stable long-term single-neuron tracking across memory circuits.
Status: In prep / unpublished manuscript
• Conducted large-scale hippocampal electrophysiological recordings in behaving mice across multiple environments, supporting experimental design with custom Arduino coding, DLC, perfusions, and imaging
• Extracted and analyzed neural population dynamics from high-dimensional electrophysiological data; analyzed place cell stability across ~300-day recording in the single-cell level by using spike sorting